HydroxyBMD³ AM + PM: Supplements for Bone Health, Joint and Cardiovascular Support (Month 2)
Most supplements for bone health are a calcium tablet and a vitamin D softgel. HydroxyBMD³ is built as a two-part daily system instead, because bone is not made of calcium alone. The AM formula supplies olive polyphenols, vitamin K2 as MK-7, choline, and a citrus flavonoid aimed at gut absorption. The PM formula delivers two forms of calcium plus chelated minerals during the body's natural overnight repair cycle. Every ingredient is named on this page at its branded, clinically studied source — Bonolive®, K2VITAL™, MicrobiomeX®, VitaCholine®, Albion Minerals® — with no proprietary blends hiding the amounts. It is professional-grade and adjustable, so you and your physician change what you take rather than accept a fixed multivitamin. This page is the Month 2 supply, $105.00.
If you're building out a broader bone health routine, HydroxyBMD³ pairs naturally with the Juvent 1000N Micro-Impact Platform, and if osteopenia or menopause-related bone loss is what brought you here, see vibration plate for osteoporosis and bone health or supplements and support for osteopenia.
Inside HydroxyBMD³: A Calcium and Bone Density Supplement Panel, Ingredient by Ingredient
Anyone searching for a calcium and bone density supplement deserves to see the actual panel rather than a proprietary blend. Here is the whole thing.
AM: Bonolive® olive polyphenols, the subject of randomized placebo-controlled trials in post-menopausal women; MicrobiomeX® citrus flavonoid, included for gut absorption; VitaCholine® choline; K2VITAL™ vitamin K2 as 99.7% all-trans MK-7, chosen for that isomer purity rather than for cost.
PM: microcrystalline hydroxyapatite (MCHA) sourced from New Zealand, supplying calcium and phosphate with minerals in their natural ratio; Di-Calcium Malate from Albion Minerals®, whose chelated mineral program carries more than 160 publications; Di-Magnesium Malate.
Other ingredients: pullulan capsules and 100% GMO-free tapioca — that is the entire list. Two calcium forms, two timed formulas, every raw material named and traceable to its supplier. Albion Minerals®, VitaCholine®, and K2VITAL™ are registered trademarks of Balchem Corporation or its subsidiaries. Each ingredient above is described with the published research on that specific ingredient — those findings describe the ingredient studies, not a promised outcome from taking HydroxyBMD³. Read more on how bioavailability shapes supplement effectiveness, or the research behind why bone loss accelerates after menopause.
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HydroxyBMD³ AM + PM: Supplements for Bone Health, Joint and Cardiovascular Support (Month 2)
The Supplement System
Taking vitamins in the morning maximizes their response. AM consists of a perfect blend of micronutrients scientifically formulated to kick start your body and support optimal bone, joint, and cardiovascular health. Its exceptional high-quality ingredients are backed by Clinical Studies. Below are some of the unique benefits of these ingredients.
Bonolive®
- BONE HEALTH BENEFITS Bonolive® is clinically proven to improve bone health in postmenopausal women. A randomized, double-blind, placebo-controlled study proved that Bonolive® has significant effects on bone-building cells (osteoblasts) and bone mineral density. In this study, a 32% increase in osteocalcin levels (μg/L) was observed over 12 months. This finding was statistically significant, and it indicated that there was an increase in osteoblast activity (bone formation). Furthermore, DEXA scans showed that women taking Bonolive® displayed protection of bone mineral density at the lumbar spine and a higher gain of bone mineral density at the femoral neck compared to those taking a placebo.
- JOINT FUNCTIONALITY A randomized, double-blind, placebo-controlled trial that was conducted in collaboration with Nestlé health science showed a significant (46%) decrease in knee pain after 6 months based on the KOOS (Knee injury and Osteoarthritis Outcome Score) as well as a significant change in knee discomfort while walking based on a VAS score (high pain group).
- POST-MENOPAUSAL SYMPTOM RELIEF In this consumer study, we investigated the effect of Bonolive® on self-assessed post-menopause symptoms in healthy post- menopausal women. Self-assessed post-menopausal symptoms scores improved significantly after 14 days and after 28 days Bonolive® supplementation compared to baseline.
MicrobiomeX®
- GUT MICROBIOME MODULATION Clinical research has shown that daily consumption of 500mg of MicrobiomeX® beneficially modulates the gut microbiota. The growth of specific bacterial groups, namely Clostridium cluster XIVa is promoted and particularlythe species belonging to the genus Roseburia spp, which are well-known for their butyrate-producing property and many beneficial health effects
- SHORT-CHAIN FATTY ACID After 12 weeks of 500mg MicrobiomeX consumption, a significant increase in the butyrate proportion of the total SCFA was observed. Furthermore, the butyrate over acetate ratio significantly increased in the MicrobiomeX group compared to the placebo group. Butyrate has health-promoting effects such as positively affecting gut barrier function and lowering gut inflammation.
- GUT INFLAMMATION & IMMUNE HEALTH After 12 weeks of daily supplementation with 500mg of MicrobiomeX®, a strong reduction in faecal calprotectin was shown compared to the placebo group. Calprotectin is an important biomarker of gut inflammation, and its reduction suggests a decrease in pathogen load in the gut.
VitaCholine is considered superior to other forms of choline for several reasons:
- Purity and Safety: VitaCholine is produced through a stringent process that ensures its purity and safety. It is free from contaminants and unwanted additives. It is made using only natural L(+) tartaric acid.
- Enhanced Bioavailability: VitaCholine is highly bioavailable, meaning it is easily absorbed and utilized by the body. This ensures that more of the nutrient reaches the cells where it is needed.
- Stability: VitaCholine is stable and maintains its efficacy over time, making it a reliable source of choline.
- Research-Backed: Numerous studies support the efficacy and benefits of VitaCholine, providing a solid scientific basis for its use.
K2VITAL™ is patented, typically 99.7% all-trans K2 MK-7. Identical to the K2 molecule found in nature and fully bioactive. Vitamin K2 all-trans MK-7 is the biologically active form of vitamin K2, a fat-soluble vital vitamin that supports calcium metabolism. Vitamin K2 activates vitamin K-dependent proteins which help move calcium to where it needs to be in the body, supporting bone and heart. It’s responsible for activating Vitamin K-dependent proteins, helping deposit calcium into the bone.
HYDROXYBMD3 PM is designed to work, while you sleep, delivering two types of calcium and minerals to help with bone building recovering during the body’s natural repair cycle.
Albion Minerals are inorganic mineral salts, like phytates and oxalates, prevalent in seeds, grains, and legumes, can bind to minerals like calcium, iron, and zinc, reducing their absorption. This isn’t the case with chelated minerals, making them ideal for vegetarians and vegans and plant-based supplements. Unlike commonplace, inorganic minerals, Albion mineral amino acid chelates emulate nature’s packaging, optimizing absorption for optimal benefits. Albion chelates form robust bonds with ligand molecules, rendering unique nutritional attributes.
CALCIUM Di-Calcium Malate, produced by Albion Minerals, is a compound structured with two moles of calcium attached to one mole of malic acid. It is designed to be better absorbed than calcium carbonate, maintaining elevated serum calcium levels for a longer period. This compound is particularly useful for bone health and supports normal nerve function. Di-Calcium Malate’s buffer capacity leads to significantly less gas creation and acid rebound compared to calcium carbonate. It is not water-soluble but dissolves at more acidic pH levels.
DI-MAGNESIUM MALATE Albion’s magnesium malate has been shown to provide more bioavailable magnesium compared to other forms, making it easier on the gastrointestinal system and potentially offering several health benefits such as improvements in mood, blood sugar control, exercise performance, and chronic pain.
MICROCRYSTALLINE HYDROXYAPATITE Microcrystalline hydroxyapatite (the best sourced from New Zealand) is a calcium compound that contains minerals in their natural ratios, along with residues of matrix, proteins, and glycosaminoglycans (MCHA). It supports bone mineral composition and can potentially reduce the risk of degenerative joint issues.
Other ingredients: Pullulan (100% GMO free tapioca)
Albion Minerals®, VitaCholine®, and K2VITAL™ are registered trademarks of Balchem Corporation or its subsidiaries.
These statements have not been evaluated by the US Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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