The Science Behind Synergistic Nutrients: Why HydroxyBMD³™ Works as a System, Not a Single Supplement

Some things were designed to function better when they’re together. Jogging and running shoes, a BLT with the L and the T, a bicycle with wheels—all these things work synergistically to deliver the best results. 

The same thing goes for the synergistic nutrients found in Juvent’s HydroxyBMD³™. The AM/PM system functions as a comprehensive, multi-component supplement for bone health designed to work in tandem with the body’s 24-hour circadian rhythms. By targeting different physiological processes at just the right time of the day and night, the system outperforms a once-a-day regimen, giving the body what it needs when it needs it most.

Launched at the National Bone Health & Osteoporosis Foundation Interdisciplinary Symposium in April 2025, HydroxyBMD³™ is considered a revolutionary supplement system for its ability to address issues related to menopause and andropause. Its clinically validated and patented formulation is aimed at improving bone, joint, skin, and cardiovascular health, and helping improve gut health through a natural, citrus-based Flavobiotic called MicrobiomeX, which modulates microbiome composition.

How HydroxyBMD³™ Contributes to Bone Health

HydroxyBMD³™ is appropriate for men and women, is gluten-free, non-GMO, and vegetarian. Its AM/PM formulation is the key to its innovative approach to supplementing your diet with essential nutrients for bone health.

The AM formula prepares your body for the demands of your day by maximizing the effects of its ingredients. It delivers essential micronutrients associated with bone-building and joint health by supporting efficient calcium metabolism, activating proteins that help deposit calcium into bones.

The system’s PM formula works while you sleep, delivering a host of compounds that include both Di-Calcium Malate, which supports bone health and nerve function, and Di-Magnesium Malate, which supports bone health and muscle recovery. Its components’ dual action can aid in energy production and muscle relaxation, which helps the body repair tissue.

By combining highly bioavailable chelated minerals and specialized nutrients, the synergistic impact of the HydroxyBMD³ system improves bone density, quality, and strength, and can be especially beneficial to post-menopausal women, those coping with knee pain, and anyone looking to improve their skeletal health.

A One, Two, Three Approach to Holistic Bone Health

By combining the HydroxyBMD³ AM/PM supplements for bone health with gentle physical movement every day, you provide your skeleton with triple-action support. Bones require a combination of proper nutrients and the right type of exercise to become stronger, increase density, and maintain their natural integrity.

If part of the reason you’re including the HydroxyBMD³ AM/PM system in your daily regimen is to help with chronic pain and mobility, obtaining the mechanical loading exercises your bones need to continue healthy remodeling might not be feasible every day.

This is why the Juvent Micro-Impact Platform® was designed. The Juvent platform is a clinically proven device the size of a bathroom scale equipped with intelligent software, sensors, and a precision mechanism that delivers low-magnitude mechanical stimuli (LMMS). LMMS simulates the benefits of gentle exercise using micro-impact technology – vibrations calibrated to your body’s natural frequency. This is delivered up through your feet without putting stress on your body or your joints.

By using the Juvent Micro-Impact Platform for just 20 minutes per day, and implementing the HydroxyBMD³ AM/PM system, you can provide your body with a holistic approach to bone and joint health.

Learn more about our HydroxyBMD³ AM/PM system and the Juvent Micro-Impact Platform. Get in touch with our team today!

These statements have not been evaluated by the U.S. Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

FDA Disclaimer

In the US, the Juvent device is considered investigational for the treatment of osteoporosis or improvement/maintenance of bone mineral density and our claims have not been reviewed or cleared by the FDA to treat any disease or condition. The JUVENT® Micro-Impact Platform® is Registered as a Class I medical device for exercise and rehabilitation.