



HydroxyBMD2 PM Natural Bone Health Supplement
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The HydroxyBMD2 Advantage: Key Ingredients and Their Benefits
HydroxyBMD2 has many natural ingredients that support bone health, including:
- Calcium: HydroxyBMBD2 lets you control the amount of calcium and minerals you get from the supplement. The AM supplement has a calcium-free option, and the PM has a natural chelated calcium mineral add-on.
- New Zealand microcrystalline hydroxyapatite concentrate (MCHC): The New Zealand MCHC is a complex crystal compound with various trace elements for healthy bone structures.
- Cytocal RP: Is a multi-amino acid calcium chelate using Biotron mineral processing technology.
- Whole food bamboo extract: Whole food bamboo extract is a bioactive form of silica that helps the body absorb calcium, magnesium and potassium.
- MK7: Is the active form of Vitamin K2 that regulates calcium in the body by delivering it to the bones.
- Chelated minerals: Provide the maximum bioavailability and are less likely to cause gastrointestinal discomfort than other minerals.
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HydroxyBMD2 PM Natural Bone Health Supplement
GET SERIOUS ABOUT YOUR BONE HEALTH
NEW & IMPROVED - We took your feedback and the latest research and built a better supplement.
- Glass bottles - no more plastic pollution and bisphenols
- Easy to swallow capsules - no tablets
- Lower Price - 30-40% less cost
- The best ingredients
- No Strontium
- A Whole Food Silica
SOLVING THE BONE HEALTH PUZZLE
Whether you’ve just been diagnosed with low bone mineral density, or you believe that you are at risk, or you are several years into your bone health regimen and want to make sure that you are doing your best: Juvent has you covered.
You see we are a company committed to being a key partner in your lifelong bone health journey. For over 25 years Juvent has represented the world’s safest and most effective bone health exercise technology. Our valued customers asked us to offer an equally impressive supplement. After years of research and sourcing, we believe we have the best.
The HydroxyBMD2 System is unique in many ways and allows you and your physician the flexibility to match YOUR needs. It's not a one size fits all solution that is so often your only choice.
What makes this Professional Quality Bone Health System so Unique?
- Bonolive a pharmaceutical-grade olive leaf extract which improved bone and cardiovascular health in clinical studies[1-19].
- HydroxyBMD PM: A chelated, natural calcium/mineral add-on allowing you and your physician to decide how much calcium and minerals are right for you.
- A New Zealand microcrystalline hydroxyapatite concentrate (MCHC): a complex crystalline compound containing numerous essential trace elements that naturally occur in healthy bone.
- Patented Chelated Calcium for maximum bioavailability.
- A whole food form of silica that assures maximum absorption.
These are just some of the highlights of this powerful system. But equally as important is the assurance that only the highest quality ingredients have been used and what is on the label is what is in the product.
We believe that HydroxyBMD2 coupled with our Micro-Impact Platform, and your physician's guidance will be key to solving your bone health puzzle.
Discover the many benefits of Our Unique Ingredients
Olive fruits provide essential components of the Mediterranean diet known for being associated with improved cardiovascular and overall health.[1,2] Historically, olive leaves have been used in folk remedies to improve digestive, cardiovascular, and skin conditions. One of the key components in BONOLIVE is oleuropein, a powerful phytonutrient unique to the olive tree. At a cellular level oleuropein promotes bone formation by inhibiting adipocyte differentiation, and enhancing differentiation into osteoblasts.[3,4,5,6]
The Benefits of Bonolive
- BonOlive provides powerful antioxidant support at the cellular level*
- BonOlive helps support cardiovascular health*
- BonOlive may improve bone health*
- Now has also been shown to reduce joint pain.
Bonolive provides powerful antioxidant support at cellular level
In the past years, interest in natural antioxidants as bioactive components of food has been rising. The positive effects of diets rich in fruits, vegetables and olive oil on overall health have been attributed partly to certain compound as phenolic compounds.[*3] Oleuropein gives the bitterness taste of olive oil but is also the major phenolic compound in olive leaves that has been studied for its antioxidant activity involving in promising results with respect to its effect on human health.[*3,5,7] The daily consumption of olive oil in population that follow the Mediterranean diet, provides enough oleuropein in the body to supply protection against free radicals and lipid peroxidation in humans.[*8] The antioxidant abilities, the scavenging abilities, the chemistry and pharmacological aspects of oleuropein have been widely studied and are well known.[7,9,10]
Bonolive helps support cardiovascular health*
For decades, the Mediterranean diet has been considered to be one of the most healthy. In the 1960's, scientific works started to observe the positive effect of overall cardiovascular health in population that followed the Mediterranean diet.[*11] Olive oil is the most popular dietary liquid from the Mediterranean diet and much of the evidence of its beneficial health is attributed to oleuropein, the major phenolic in olive leaves.[12,13,14,15,16]
Bonolive may improve bone health*
Epidemiological studies have shown that the incidence of bone loss was lower in the Mediterranean basin where traditional Mediterranean diet that include consumption of olive oil is widely consumed by the population.[17] Moreover, experimental models have been able to show that oleuropein is the phenolic compound from olive leaves involved in hindering, the loss of bone mass suggesting its possible key role in improving bone health.[*18,19]
Clinically Proven
BonOlive is a clinically proven bone health supplement. A randomized, double-blind, placebo-controlled study proved that BonOlive has significant effects on stimulation of bone building cells (osteoblasts) and blood liquid profiles.
The figure illustrates the 32% increase in osteocalcin levels over 12 months, which was statistically significant and indicates an increase in osteoblast activity (bone formation). Also blood liquid markers improved. A significant treatment effect was observed for total cholesterol LDL-cholesterol and triglyceride levels. Finally, DEXA scans showed subjects taking BonOlive displayed a protection of bone mineral density at the femur neck compared to those taking placebo.
Superior Bioavailability
Furthermore, results of a pharmacokinetic study shown the intake of BonOlive leads to an excellent bioavailability of bioactive metabolites in the target population for use of BonOlive.
Dr. M.Taher Fouad founded Biotron Laboratories in 1979. His passion for health and science converged in his commitment to discovering the role of minerals and trace elements in the human body. Biotron's history is inextricably linked to Mineral Amino Acid Chelates and their role in human nutrition, and Dr. Fouad's pioneering of these efforts. Today Biotron carries forward Dr. Fouads's lifework with a primary focus on scientifically validated mineral chelates and complexes.
Following in his father's footsteps, Dr. Gameil T. Fouad now presides over daily operations at Biotron. Gameil earned his B.S. in Human Biology at the University of Utah and went on to earn his Ph.D. at the Department of Molecular and Medical Genetics at the Oregon Health & Science University.
In his role as President, Gameil approaches mineral nutrition from a unique industry perspective, bringing new ideas to bear on minerals. Along with his expert team, Gameil actively applies these tools to the health and nutrition field with the aim of developing mineral products that are highly compatible with human physiology on a molecular level.
To date, the Biotron Process has achieved widespread recognition as a unique and scientifically valid technique, which utilizes the complete amino acid profile derived from enzymatic treatment of isolated vegetable proteins–a process resulting in authentic Mineral Amino Acid Chelates and Complexes.
Chelated Minerals for Human Nutrition - Calcium is essential
Where nutritionally essential minerals are concerned, calcium is truly in a class by itself. The daily requirements for calcium are over 1,000 milligrams per day for most adults. It is hard to overemphasize the roles calcium plays in the body. Calcium is involved in a wide array of biological processes - from intracellular signaling to neurotransmission and muscle contraction. Despite these various functions, it is calcium's definitive role in supporting bone health that makes this nutrient so vital. It's one of the few essential nutrients for which an FDA-approved claim can be made. It is difficult to overemphasize the importance of achieving peak bone mass in adolescence and early adulthood to minimize the risks of osteoporosis later in life.
Unfortunately, most women fail to get enough calcium from diet alone. For many, supplementation is indispensable to achieving adequate daily intake. Not all forms of calcium are created equally and controversy over which type is best continues to be a matter of debate. Its thought that organically-bound calcium is preferentially absorbed when compared to widely used inorganic forms such as calcium carbonate. Demonstrating this experimentally is challenging. Because if its importance, calcium levels in the blood are very tightly regulated by the body. Parathyroid hormone (PTH) - among other hormonal control systems - function to maintain this delicate balance.
All these Amazing Ingredients come together in the HydroxyBMD2 System
- Provide a Multifaceted Approach to Bone Maintenance and Strength*
- Provide Foundational Bone Support with Silica from Bamboo Extract)
- Support Bone Collagen Formation, Bone Mineral Density, and Bone Calcium Binding Sites*
- Provide a Complementary Combination of Micronutrients*
Bonolive Olive Leaf Extract
Bonolive is a pharmaceutical-grade olive leaf extract that features a unique polyphenol complex (40% polyphenols), including oleuropein. This proprietary olive extract preparation is fully water-soluble, which makes its oral bioavailability superior. Historical and traditional use, as well as clinical testing and toxicological assessment, confirm the safety of its oral consumption.[1,2]
Research has shown that olive polyphenol bioactivity is associated with increased osteoblast formation, increased extracellular matrix mineralization, and overall bone maintenance.[3] Five preclinical studies in a well-established rat model for bone health demonstrated that olive polyphenols exert protective effects on the formation and maintenance of bone.[4,5] In addition, a randomized, double-blind, placebo-controlled clinical study provided strong support for Boneolive promoted a statistically significant improvement (32% increase) in levels of the bone formation marker osteocalcin over a 12-month period. Furthermore, DEXA scan results suggested that Bonolive supplementation positively supported BMD at the lumbar spine and the femur neck compared to a placebo.[6] The treatment group also experienced reduced adipocyte formation and a positive effect on lipid metabolism (i.e., cholesterol and triglycerides), confirming Boneolive’s double mode of action. To positively influence bone health and cardiovascular health.
In the Evening:
- Supports Bone Metabolism
- Supports Bone Strength*
- Provides Micronutrients for Utilization in Bone Production and Structure*
HydroxyBMD2PM is a well-researched, standardized extract from one of the world’s safest premium sources of bone - free-range New Zealand cattle. HydroxyBMD2 PM contains microcrystalline hydroxyapatite concentrate (MCHC), a complex crystalline compound containing calcium, phosphorus, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements that naturally comprise healthy bone.*
HydroxyBMD2 PM delivers 250mg of MCHC per capsule along with additional calcium and magnesium in the form of highly absorbable Cytocal, Vitamin D, in the form of cholecalciferol, supports intestinal calcium absorption and homeostasis in the body and completes the comprehensiveness of this bone-support formula.*
Directions: Take two capsules with your meal daily in the afternoon/evening.
(Consult your healthcare practitioner prior to use. Individuals taking medication should discuss potential interactions with their healthcare practitioner. Do not use if tamper seal is damaged. The labeling on this product does not comply with California’s Proposition 65. Therefore, this product may not be sold in California.)
Does not contain: Wheat, gluten, yeast, soy protein, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organism (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
Storage: Keep tightly closed in a cool, dry place out of reach of children.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Bonolive® is a trademark of BioActor.
Scientific References BONOLIVE
1. Covas M, Ruiz-Gutierrez V., De La Torre R, et al. Minor Components of Olive Oil: Evidence to Date of Health Benefits in Humans. Nutr Rev. 2006;64:20-30.
2. Buckland G. and Gonzales CA. The role of olive oil in disease prevention: a focus on the recent epidemiological evidence from cohort studies and dietary intervention trials. Brit J Nutr. 2015;113:S94-S101.
3. Benavente-Garcia O, Castillo J. Lorente J et al. Antioxidant activity of phenolics extracted from Olea europaea L. leaves. Food Chem. 2000;68:457-462.
4. Ghedira K. L’olivier. Phytotherapie. 2008;6:83-89.
5. Barbaro B, Toietta G, Maggio R et al. Effects of the olive-derived polyphenol oleuropein on human health. Int J Mol Sci. 2014;15:18508-15524.
6. Ben Salem M, Affes H, Ksouda K, et al. Pharmacological Activities of Olea europaea Leaves. J Food Processing and Preservation. 2015;39:3128-3136.
7. Wichers HJ, Espin JC and Soler-Rivas C. Oleuropein and related compounds. J Sci Food and Agric. 2000;80:1013-1023.
8. Perona JS, Cabello-Moruno R and Ruiz-Gutierrez V. The role of virgin olive oil components in the modulation of endothelial function. J Nutr Biochem. 2006;17:429-445.
9. Tuck KL and Hayball PJ. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem. 2002;13:636-644.
10.Tripoli E, Giammanco M, Tabacchi G et al. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev. 2005;18:98-112.
11.Psaltopoulou T, Naska A, Orfanos P, and al. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. The American journal of clinical nutrition. 2004;80:1012.
12.Covas MI. Olive oil and the cardiovascular system. Pharmacol Res. 2007;55:175-186.
13.Zacharias E. The Mediterranean Diet: A Clinician’s Guide for Patient Care. Publisher: Springer New York. 2012.
14.Waterman E. and Lockwood B. Active components and clinical applications of olive oil. Alternative medicine review: J Clin Ther. 2007;12:331.
15.Omar SH. Oleuropein in olive and its pharmacological effects. Scientia pharmaceutica. 2010;78:133-154.
16.Preedy VR, Watson RR. Olives and Olive Oil in Health and Disease Prevention. 1st ed. Amsterdam; Boston: Elsevier/Academic Press; 2010;2013.
17.Santiago-Mora R, Casado-Diaz A. De Castro MD et al. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow. Osteoporosis Int. 2011;22:675-684.
18.Puel C, Mathey J, Agalias A et al. Dose-response study of effect of oleuropein, an olive oil polyphenol in an ovariextomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 2006;25:859-868.
19.Garcis-Martinez O, Rivas A, Ramos-Torrecillas J. et l. The effect of olive oil on osteoporosis prevention. Int J Food Sci nutr. 2014;65:834-840
Scientific References for HydroxyBMD2 AM's Formulation
1. Filip R, Possemiers S, Heyerick A, et al. Twelve-month consumption of a polyphenol extract from olive in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with osteopenia. J Nutr Health Aging. 2015 Jan; 19(1):77-86. [PMID:9483660]
2. Clewell AE, Beres E, Vertesi A., et al. A comprehensive toxicological safety assessment of an extract of Olea Europea L. leaves (BonoliveTM). Int J Toxicol. 2015 Dec 10. pii: 1091581815619764. Epub ahead of print.[PMID: 26658007
3. Santiago-Mora R, Casado-Diaz A, De Castro MD, et al. Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone narrow. Osteoporos Int. 2011 Feb;22(2):675-84. [PMID: 20495905] 4. Puel C, Mardon J, Agalias A, et al. Major phenolic compounds in olive oil modulate bone loss in an ovariectomy/inflammation experimental model. J Agric Food Chem. 2008 Oct. 22;56(20):9417-22. [PMID: 18800805]
5. Puel C, Mahey J, Agalias A, et al. Dose-response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammation experimental model of bone loss in the rat. Clin Nutr. 2006 Oct;25(5):859-68.[PMID: 16740345].
6. Puel C, Quintin A, Angalias A, et al. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Br J Nutr. 2004 Jul;92(1):119-27. [PMID: 15230995]
7. Puel C, Mardon J, Kati-Coulibaly S, et al. Black Luques olives prevented bone loss caused by ovariectomy and talc granulomatosis in rats. Br J Nutr. 2007 May;97(50:1012-20. [PMID: 17408530]
8. Hagiwara K, Goto T, Araki M, et al. Olive polyphenol hydroxytyrosol prevents bone loss. Eur J Pharmasol. 2011 Jul 15;662(1-3):78-84. [PMID: 21539839]
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
We believe that HydroxyBMD2 coupled with our Micro-Impact Platform, and your physician's guidance will be key to solving your bone health puzzle.
If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, within 24 hours on weekdays.
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Clinically Researched
Juvent’s patented micro-impact technology delivers gentle vibrations that stimulate bone and muscle health. This low-impact therapy has been proven to enhance circulation, improve balance, and support recovery—all without putting stress on your joints.
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