CLINICAL BENEFITS OF JUVENT’S MICRO-IMPACT PLATFORM®

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BIOMECHANICAL SIGNALS AND BONE MORPHOGENESIS:

Beyond physical support, the skeletal system serves many physiological functions such as endocrine, stem cell production hematopoietic and mesenchymal (osteo-, chondra-, adipo-, angio, neuro, and myogenic).  Proper skeletal health is vital for physical strength and proper maintenance of the endocrine and circulatory systems. Developing optimal bone mineral density (BMD) during childhood and adolescence is essential to establishing sufficient bone mass to support and maintain skeletal health throughout life. To date, prevention of bone loss has been approached principally through nutrition, vitamin supplements, and pharmacologic intervention. New research shows the developing skeleton can modify its structure and strength in response to biomechanical loading induced by functional activity1-2. As a supplement to traditional exercise, brief daily exposure to low-magnitude mechanical stimuli (LMMS) has demonstrated potential as an adjunct bone therapy with anabolic and anti-resorptive properties3. LMMS involves standing on a pure linear displacement platform that transmits vertical accelerations below 1g to weight-bearing bones4. These mechanical signals are anabolic to the skeletal system by biasing mesenchymal stem cell populations toward osteoblastogenesis and improved bone mineralization5. Animal studies and several human clinical studies and trials have demonstrated LMMS’s efficacy in improving bone health through gains in trabecular bone volume fraction and cortical area6-14.

JUVENT’S MICRO-IMPACT PLATFORM: THE LEADING LMMS TECHNOLOGY FOR HEALTHCARE AND SPORTS APPLICATIONS

This clinically proven fitness device is the result of $45-million of R&D and 20+ worldwide patents. Its’ unique LMMS is a patented combination of intelligent software, sensors, and a precision mechanism that optimizes a signal personalized to each user’s resonant frequency. Its’ signal operates within a safe range of frequencies(32Hz-37Hz) and force(0.3-0.4g’s). Unlike high power whole body vibration (hpWBV) ‘shakers’, Juvent provides safe, sub-millimetric micro-impacts.  These generate the desired physiological response without risk of injury using energy levels far below OSHA and ISOs safety guidelines allowing use with even children and frail adults.

JUVENT’S MICRO-IMPACT THERAPY:  THE MOST CLINICALLY STUDIED LMMS PLATFORM IN THE WORLD

Juvent’s Micro-Impact therapy is unlike any other vibration platform technology. It’s a clinically proven device differentiated by research. Table 1 We have provided specific differences in Table 2.

Table 1 - Completed clinical studies using Juvent’s Micro-Impact Platform®

Lit. cited:

1. Ducher G, Bass SL, Saxon L, Daly RM. Effects of repetitive loading on the growth-induced changes in bone mass and cortical bone geometry: a 12-month study in pre/peri- and postmenarcheal tennis players. J Bone Miner Res. 2011;26(6):1321–9.
2. Kontulainen S, Sievanen H, Kannus P, Pasanen M, Vuori I. Effect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res. 2002;17(12):2281–9.
3. Chan ME, Uzer G, Rubin CT. The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis. Curr Osteoporos Rep. 2013;11(1):36–44.
4. Xie L, Jacobson JM, Choi ES, et al. Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton. Bone. 2006;39(5):1059–66.
5. Nagaraja MP, Hanjoong Jo. The role of mechanical stimulation in recovery of bone loss—high versus low magnitude and frequency of force. Life. 2014;4:117–130. doi:10.3390/life4020117
6. Xie L, Rubin C, Judex S. Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations. J Appl Physiol (1985). 2008;104(4):1056–62.
7. Vanleene M, Shefelbine SJ. Therapeutic impact of low amplitude high frequency whole body vibrations on the osteogenesis imperfecta mouse bone. Bone. 2013;53(2):507–14.
8. Mogil RJ. Effect of low-magnitude, high-frequency mechanical stimulation on BMD among young childhood cancer survivors: a randomized clinical trial. JAMA Oncol. 2016 Jul 1;2(7):908–14. doi:10.1001/jamaoncol.2015.6557.
9. Leonard MB, Shults J, Long J, Baldassano RN, Brown JK, Hommel K, Zemel BS, Mahboubi S, Howard Whitehead K, Herskovitz R, Lee D, Rausch J, Rubin CT. Effect of low-magnitude mechanical stimuli on bone density and structure in pediatric Crohn’s disease: a randomized placebo-controlled trial. J Bone Miner Res. 2016 Jun;31(6):1177–88.
10. Wren TAL, Lee DC, Hara R, et al. Effect of high-frequency, low-magnitude vibration on bone and muscle in children with cerebral palsy. J Pediatr Orthop. 2010;30:732–738.
11. Fung EB, Gariepy CA, Sawyer AJ, Higa A, Vichinsky EP. The effect of whole body vibration therapy on bone density in patients with thalassemia: a pilot study. Am J Hematol. 2012 Oct;87(10):E76–9. doi:10.1002/ajh.23305.
12. Gilsanz V, Wren TA, Sanchez M, Dorey F, Judex S, Rubin C. Low-level, high-frequency mechanical signals enhance musculoskeletal development of young women with low BMD. J Bone Miner Res. 2006 Sep;21(9):1464–74.
13. Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K. Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J Bone Miner Res. 2004 Mar;19(3):343–51.
14. Ward K, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res. 2004 Mar;19(3):360–9. Epub 2004 Jan 27.
15. Muir J, Judex S, Qin YX, Rubin C. Gait Posture. 2011 Mar;33(3):429–35. doi:10.1016/j.gaitpost.2010.12.019. Epub 2011 Jan 26.
16. Stewart JM, Karman C, Montgomery LD, McLeod KJ. Am J Physiol Regul Integr Comp Physiol. 2005 Mar;288(3):R623–9. Epub 2004 Oct 7.